missing translation for 'onlineSavingsMsg'
Learn More

NU 6140, Tocris Bioscience™

Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

Brand:  Tocris (Bio-Techne) 330150

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

 View more versions of this product

Product Code. 13442744

  • £556.42 / 50mg

Estimated Shipment
28-06-2019

Please to purchase this item. Need a web account? Register with us today!


Description

Description

Cyclin-dependent kinase 2 (cdk2) inhibitor (IC50 values are 0.42 - 1.1 μM). Displays some selectivity for cdk2 (IC50 value = 0.94 μM for cdk4 and >2.3 μM for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC50 values are 0.035 and 0.067 μM for aurora kinase B and A, respectively).
Specifications

Chemical Identifiers

444723-13-1
422.533
cdk2 inhibitor iv, nu6140, 4-6-cyclohexylmethoxy-9h-purin-2-ylamino-n,n-diethylbenzamide, cdk2 inhibitor iv, d04wfn, nu hplc, 4-6-cyclohexylmethoxy-9hpurin-2-ylamino-n,n-diethyl-benzamide, 4-6-cyclohexylmethoxy-1h-purin-2-yl amino-n,n-diethylbenzamide, 4-6-cyclohexylmethoxy-7h-purin-2-yl amino-n,n-diethylbenzamide, 4-6-cyclohexylmethoxy-9h-purin-2-yl amino-n,n-diethylbenzamide
4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
C23H30N6O2
XHEQSRJCJTWWAH-UHFFFAOYSA-N
10202471
CCN(CC)C(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)NC=N3

Specifications

NU 6140
444723-13-1
cdk2 inhibitor iv, nu6140, 4-6-cyclohexylmethoxy-9h-purin-2-ylamino-n,n-diethylbenzamide, cdk2 inhibitor iv, d04wfn, nu hplc, 4-6-cyclohexylmethoxy-9hpurin-2-ylamino-n,n-diethyl-benzamide, 4-6-cyclohexylmethoxy-1h-purin-2-yl amino-n,n-diethylbenzamide, 4-6-cyclohexylmethoxy-7h-purin-2-yl amino-n,n-diethylbenzamide, 4-6-cyclohexylmethoxy-9h-purin-2-yl amino-n,n-diethylbenzamide
CCN(CC)C(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)NC=N3
422.533
422.52
50mg
C23H30N6O2
XHEQSRJCJTWWAH-UHFFFAOYSA-N
4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
10202471
>99%
Videos