NOS2 Rat anti-Mouse, APC, Clone: CXNFT, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5920-82

Code: Z2

Additional Details:
Additional Details: Weight: 0.10000kg



Disclaimers: For Research Use Only.

Product Code. 15409513

Quantity Price
1 £ 198.54 / 100µL
EU Stock 9
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Description and Specification

Specification

Format Conjugated
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen NOS2
Species Reactivity Mouse
Concentration 0.2mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry (Intracellular Staining)
Isotype IgG2a
Regulatory Status RUO
Clone CXNFT
Conjugate APC
Gene Alias iNOS, nitric oxide synthase 2
Host Species Rat
Quantity 100μg

This CXNFT monoclonal antibody reacts to mouse NOS2 (inducible NOS, iNOS). Nitric oxide synthase enzymes catalyze the formation of nitric oxide from L-arginine through an NADPH- and oxygen-dependent mechanism. There are three isoforms of NOS that are encoded by three separate genes. NOS1 (neuronal NOS, nNOS) and NOS3 (endothelial NOS, eNOS) are constitutively expressed, while NOS2 is induced in response to bacterial endotoxins and inflammatory cytokines such as IFN gamma and TNF alpha. NOS2 is expressed by myeloid-derived suppressor cells and M1 macrophages but not alternatively activated M2 macrophages. NOS enzymes are functionally active only when they form homodimers, and dimerization of NOS2 occurs at steady-state concentrations of free Ca2+ such that NOS2 is functionally active when it is produced.