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CD271 (NGF Receptor), clone: ME20.4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9400-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15537596

  • £63.17 / 25µg


EU Stock 2
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Description

Description

Description: The monoclonal antibody ME20.4 recognizes CD271, a 75kDa type I transmembrane protein that belongs to the low-affinity neurotrophin receptor and tumor necrosis factor receptor superfamily. CD271 is expressed by neurons, Schwann cells, melanocytes, mesenchymal stem/stromal cells, neural crest stem cells, astrocytes, oligodendrocytes, and a subset of lymphoid cells including follicular dendritic cells. CD271 binds to the ligands NGF, BDNF, NTF3, and NTF4. CD271 contains a death domain which induces apoptosis and regulates cell growth and proliferation through interactions with TRAF2, TRAF4, TRAF6, PTPN13, and RANBP9.The ME20.4 monoclonal antibody recognizes human, non-human primate, mouse, rat, sheep, rabbit, cat, dog, and pig CD271.Applications Reported: This ME20.4 antibody has been reported for use in flow cytometric analysis, western blotting, microscopy, immunohistochemical staining, and immunocytochemistry.Applications Tested: This ME20.4 antibody has been tested by flow cytometric analysis of SK-N-SH cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. This ME20.4 antibody has also been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using high pH antigen retrieval and can be used at less than or equal to 5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

NGFR
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P08138, Q9Z0W1, P07174
Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR, CD271
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Sheep
Western Blot
ME20.4
Unconjugated
NGFR
Purified
NGFR
IgG1, kappa
25μg
Store at 2-8°C.
Primary
4804
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