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NF 110, Tocris Bioscience™

Potent P2X3 antagonist

Brand:  Tocris (Bio-Techne) 254850

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13451444

  • £787.92 / 50mg

Estimated Shipment date
from Supplier 24-03-2020

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Description

Description

High affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types.
Specifications

Chemical Identifiers

111150-22-2
1096.899
4,4',4,4'-carbonylbis imino-5,1,3-benzenetriylbis carbonylimino tetrakisbenzenesulfonic acid tetrasodium salt, benzenesulfonic acid,4,4',4,4'-carbonylbis imino-5,1,3-benzenetriylbis carbonylimino tetrakis-,tetrasodium salt 9ci, tetrasodium 4-3-3,5-bis 4-sulfonatophenyl carbamoyl phenyl carbamoyl amino-5-4-sulfonatophenyl carbamoyl benzamido benzenesulfonate
tetrasodium;4-[[3-[[3,5-bis[(4-sulfonatophenyl)carbamoyl]phenyl]carbamoylamino]-5-[(4-sulfonatophenyl)carbamoyl]benzoyl]amino]benzenesulfonate
C41H28N6Na4O17S4
AQJHZNCSXLBXMY-UHFFFAOYSA-J
16066783
C1=CC(=CC=C1NC(=O)C2=CC(=CC(=C2)NC(=O)NC3=CC(=CC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)(=O)[O-])C(=O)NC5=CC=C(C=C5)S(=O)(=O)[O-])C(=O)NC6=CC=C(C=C6)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+]

Specifications

NF 110
111150-22-2
4,4',4,4'-carbonylbis imino-5,1,3-benzenetriylbis carbonylimino tetrakisbenzenesulfonic acid tetrasodium salt, benzenesulfonic acid,4,4',4,4'-carbonylbis imino-5,1,3-benzenetriylbis carbonylimino tetrakis-,tetrasodium salt 9ci, tetrasodium 4-3-3,5-bis 4-sulfonatophenyl carbamoyl phenyl carbamoyl amino-5-4-sulfonatophenyl carbamoyl benzamido benzenesulfonate
C1=CC(=CC=C1NC(=O)C2=CC(=CC(=C2)NC(=O)NC3=CC(=CC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)(=O)[O-])C(=O)NC5=CC=C(C=C5)S(=O)(=O)[O-])C(=O)NC6=CC=C(C=C6)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+]
1096.899
1096.9
50mg
C41H28N6Na4O17S4
AQJHZNCSXLBXMY-UHFFFAOYSA-J
tetrasodium;4-[[3-[[3,5-bis[(4-sulfonatophenyl)carbamoyl]phenyl]carbamoylamino]-5-[(4-sulfonatophenyl)carbamoyl]benzoyl]amino]benzenesulfonate
16066783
>98%
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