Neural / Glial Antigen 2 (NG2) Mouse anti-Human, Clone: 9.2.27, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-6504-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15267717

Quantity Price
1 £ 127.8 / 100µg
EU Stock 1
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Description and Specification

Specification

Primary or Secondary Primary
Gene Alias Chondroitin Sulfate Proteoglycan, MCSP/melanoma chondroitin sulfate proteoglycan
Antigen Neural / Glial Antigen 2 (NG2)
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunoprecipitation
Isotype IgG2a
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Clone 9.2.27
Quantity 100μg
Concentration 0.5mg/mL
Format Purified
Conjugate Unlabeled

This 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250kDa N-linked glycoprotein and a >450kDa proteoglycan. NG2 is present on the surface of >90% of malignant melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia.

The 9.2.27 antibody has been reported to suppress melanoma tumor growth.