Neural / Glial Antigen 2 (NG2) Mouse anti-Human, Clone: 9.2.27, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-6504-82

100UG:ANTI-HUMAN NEURAL/GLIAL ANTIGEN 2(NG2)

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15267717

Quantity Price
1 £ 157.0 / 100µg
Estimated Shipment date
from Supplier 08-12-2016
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Description and Specification

Specification

Antigen Neural / Glial Antigen 2 (NG2)
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunoprecipitation
Clone 9.2.27
Concentration 0.5mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Chondroitin Sulfate Proteoglycan, MCSP/melanoma chondroitin sulfate proteoglycan
Host Species Mouse
Isotype IgG2a
Quantity 100μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

This 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250kDa N-linked glycoprotein and a >450kDa proteoglycan. NG2 is present on the surface of >90% of malignant melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia.

The 9.2.27 antibody has been reported to suppress melanoma tumor growth.