Neural / Glial Antigen 2 (NG2) Mouse anti-Human, Alexa Fluor 488, Clone: 9.2.27, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-6504-80

25UG ANTI-HUMAN NEURAL/GLIAL ANTIGEN 2 AF 488

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15312060

Quantity Price
1 £ 101.0 / 25µg
Estimated Shipment date
from Supplier 23-01-2017
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Description and Specification

Specification

Antigen Neural / Glial Antigen 2 (NG2)
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Clone 9.2.27
Concentration 0.5mg/mL
Conjugate Alexa Fluor 488
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Chondroitin Sulfate Proteoglycan, MCSP/melanoma chondroitin sulfate proteoglycan
Host Species Mouse
Isotype IgG2a
Quantity 25μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

This 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250kDa N-linked glycoprotein and a >450kDa proteoglycan. NG2 is present on the surface of >90% of malignant melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia.

The 9.2.27 antibody has been reported to suppress melanoma tumor growth.