Nanog Mouse anti-Human, Clone: hNanog.2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5768-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15217457

Quantity Price
1 £ 78.88 / 25µg
Estimated Shipment date
from Supplier 05-04-2017
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Description and Specification

Specification

Species Reactivity Human
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Primary or Secondary Primary
Host Species Mouse
Clone hNanog.2
Conjugate Unlabeled
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Format Purified
Concentration 0.5mg/mL
Quantity 25μg
Regulatory Status RUO
Antigen Nanog
Storage Requirements Store at 2-8°C.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The hNanog.2 antibody recognizes human Nanog, a homeobox transcription factor expressed in embryonic stem cells (ESC). Nanog is essential for self-renewal of ESC and the inner cell mass and is throught to function in the same capacity as other factors such as Oct4 and Sox2. Nanog plays a crucial role in embryonic cell fate specification following formation of the blastocyst by regulating proliferation and preventing differentiation. Nanog functions by directly binding DNA consensus sequences to activate or repress transcription. In differentiating ESC, Nanog binds to its own promoter leading to repression of expression. Nanog has been reported to be overexpressed in germ cell tumors of the gonads and central nervous system as well as breast and colorectal cancer.