Myeloperoxidase (MPO) Mouse anti-Human, PE, Clone: MPO455-8E6, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1299-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15526876

Quantity Price
1 £ 176.7 / 100 tests
EU Stock 2
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Description and Specification

Specification

Antigen Myeloperoxidase (MPO)
Clone MPO455-8E6
Regulatory Status RUO
Isotype IgG1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Quantity 100 tests
Concentration 5μL (0.5μg)/test
Species Reactivity Human
Conjugate PE
Format Conjugated
Host Species Mouse
Applications Flow Cytometry (Intracellular Staining)
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary

The monoclonal antibody MPO455-8E6 recognizes myeloperoxidase (MPO), a protein within the azurophilic granules of myeloid cells. MPO is a multimeric protein comprised of two 55kDa subunits and two 15kDa subunits. The larger subunits associate with a heme protein resulting in a greenish color. As an enzyme, MPO breaks down hydrogen peroxide and oxidizes tyrosine. The products of this reaction, hypochlorous acid and tyrosyl radical, cause the cytotoxic and killing effects characteristic of neutrophils. Myeloperoxidase is important in the diagnosis of some cancers and increases in serum levels have been shown to correlate with cardiac events.