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Musashi 2 Mouse anti-Human, Mouse, eFluor 660, Clone: C1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9677-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15530107

  • £67.82 / 25µg


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For Research Use Only.


Description

Description

The monoclonal antibody C1 recognizes human and mouse Musashi-2 (Msi2), a highly conserved RNA-binding protein. Musashi-2 contains two RNA-recognition domains and is expressed as one of two isoforms of 36 and 37kDa. Musashi 2 with its family member Musashi-1, are expressed at high levels in stem and tumor cells. During neural development, Musashi-2 is expressed in progenitor cells in the ventricular and subventricular zones, while postnatally, Musashi-2 expression is limited to multiple subsets of neurons and astrocytes in addition to adult stem cell populations. Functionally, Musashi-2 associates with Sox2 and is required for self-renewal of embryonic stem cells. Much like its role in maintaining stemness in neural progenitors, Musashi-2 is expressed in hematopoetic stem cells and plays a similar role in maintaining self-renewal. Musashi-2 has been found to be overexpressed in human myeloid leukemia and the levels of expression correlate with decreased survival. Musashi-2 may serve as a prognostic marker for acute myeloid leukemia (AML).
Specifications

Specifications

Musashi 2
C1
eFluor 660
Conjugated
IgG3
RUO
Primary
Murine
Microscopy
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
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