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Musashi-2, clone: C1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9677-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15537606

  • £151.12 / 100µg


Estimated Shipment date
from Supplier 01-06-2018
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Description

Description

Description: The monoclonal antibody C1 recognizes human and mouse Musashi-2 (Msi2), a highly conserved RNA-binding protein. Musashi-2 contains two RNA-recognition domains and is expressed as one of two isoforms of 36 and 37kDa. Musashi 2 with its family member Musashi-1, are expressed at high levels in stem and tumor cells. During neural development, Musashi-2 is expressed in progenitor cells in the ventricular and subventricular zones, while postnatally, Musashi-2 expression is limited to multiple subsets of neurons and astrocytes in addition to adult stem cell populations. Functionally, Musashi-2 associates with Sox2 and is required for self-renewal of embryonic stem cells. Much like its role in maintaining stemness in neural progenitors, Musashi-2 is expressed in hematopoetic stem cells and plays a similar role in maintaining self-renewal. Musashi-2 has been found to be overexpressed in human myeloid leukemia and the levels of expression correlate with decreased survival. Musashi-2 may serve as a prognostic marker for acute myeloid leukemia (AML).Applications Reported: This C1 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry.Applications Tested: This C1 antibody has been tested immunohistochemistry on human FFPE tissue using high or low pH antigen retrieval at less than or equal to 10 ug/mL. The C1 antibody has also been tested by western blot on reduced whole mouse brain and SK-N-SH cell lysate and can be used at less than or equal to 5 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Musashi 2
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q920Q6, Q96DH6
MSI2H, RNA-binding protein Musashi homolog 2, musashi-2
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Western Blot
C1
Unconjugated
MSI2
Purified
Msi2
IgG3, kappa
100μg
Store at 2-8°C.
Primary
124540
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