missing translation for 'onlineSavingsMsg'
Learn More

mTOR Mouse anti-Human, Mouse, Clone: F11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-2190-80

Code : Z2

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15247317

  • £48.31 / 25µg


Estimated Shipment
11-12-2017
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

This F11 monoclonal antibody reacts with human, mouse, and rat mammalian target of rapamycin (mTOR). This 289kDa serine/threonine kinase is activated via phosphorylation at Ser2448 by the PI3K/Akt signaling pathway in response to growth factors, energy, nutrients, and stress. mTOR is highly conserved amongst eukaryotes and constitutively expressed in immune (e.g. T, B, NK, dendritic cells, mast cells, and neutrophils) and non-immune tissues (e.g. heart). mTOR exists as a member of two distinct complexes, mTORC1 and mTORC2, which have differing sensitivities to rapamycin and phosphorylation targets. Rapamycin inhibits mTOR activity by binding FKBP12, which causes dissociation of mTORC1 and mTORC2. This molecule plays a critical role in cell metabolism, survival, dendritic cell maturation and activation, and protein synthesis. Deregulation of mTOR has been implicated in a variety of cancers. Studies have also suggested a role for mTOR in Foxp3 expression and regulatory T cell differentiation.
Specifications

Specifications

mTOR
F11
Unlabeled
Purified
IgG1
RUO
Primary
Murine
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25μg
Store at 2-8°C.
Monoclonal
Videos