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MRK 560, Tocris Bioscience™

γ-secretase inhibitor; attenuates amyloid plaque deposition

Brand:  Tocris (Bio-Techne) 400010

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13443954

  • £219.03 / 10mg

Estimated Shipment date
from Supplier 26-11-2019

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Description

Description

γ-secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of Aβ in the brain (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM); attenuates plaque deposition. Orally bioavailable.
Specifications

Chemical Identifiers

677772-84-8
517.91
n-cis-4-4-chlorophenyl sulfonyl-4-2,5-difluorophenyl cyclohexyl-1,1,1-trifluoromethanesulfonamide, cyclohexyl sulfone-based compound, 32, n-4-4-chlorobenzene sulfonyl-4-2,5-difluorophenyl cyclohexyl trifluoromethanesulfonamide, trifluoromethanesulfonic acid, n-4-4-chlorobenzenesulfonyl-4-2,5-difluorophenyl-cyclohexyl-amide
N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
C19H17ClF5NO4S2
WDZVWDXOIGQJIO-UHFFFAOYSA-N
11577204
C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

Specifications

10mg
677772-84-8
n-cis-4-4-chlorophenyl sulfonyl-4-2,5-difluorophenyl cyclohexyl-1,1,1-trifluoromethanesulfonamide, cyclohexyl sulfone-based compound, 32, n-4-4-chlorobenzene sulfonyl-4-2,5-difluorophenyl cyclohexyl trifluoromethanesulfonamide, trifluoromethanesulfonic acid, n-4-4-chlorobenzenesulfonyl-4-2,5-difluorophenyl-cyclohexyl-amide
C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
517.91
517.92
MRK 560
C19H17ClF5NO4S2
WDZVWDXOIGQJIO-UHFFFAOYSA-N
N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
11577204
>99%
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