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MRK 016, Tocris Bioscience™

α5-selective GABAA inverse agonist

Brand:  Tocris (Bio-Techne) 381710

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13463644

  • £183.48 / 10mg


Estimated Shipment
02-01-2019
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Description

Description

GABAA receptor inverse agonist selective for the α5-subtype (EC50 = 3 nM). Exhibits affinity at benzodiazepine binding site of recombinant human GABAA receptors (Ki values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for α3-, α1-, α2-, and α5-containing respectively). Increases long-term potentiation (LTP) in mouse hippocampal slices. Exhibits no anxiogenic or proconvulsant activity.
Specifications

Chemical Identifiers

783331-24-8
368.401
d09ihe, 2-1-methyl-1h-1,2,4-triazole-5-yl methoxy-3-tert-butyl-7-5-methyl-3-isoxazolyl pyrazolo 1,5-d 1,2,4 triazine, 3-1,1-dimethylethyl-7-5-methyl-3-isoxazolyl-2-1-methyl-1h-1,2,4-triazol-5-yl methoxy-pyrazolo 1,5-d 1,2,4 triazine, 3-3-tert-butyl-2-2-methyl-1,2,4-triazol-3-yl methoxy pyrazolo 1,5-d 1,2,4 triazin-7-yl-5-methyl-1,2-oxazole, 3-t-butyl-7-5-methylisoxazol-3-yl-2-1-methyl-1h-1,2,4-triazol-5-ylmethoxy-pyrazolo 1,5-d-1,2,4 triazine, 3-tert-butyl-7-5-methyl-isoxazol-3-yl-2-2-methyl-2h-1,2,4 triazol-3-ylmethoxy-pyrazolo 1,5-d 1,2,4 triazine, 3-tert-butyl-7-5-methylisoxazol-3-yl-2-1-methyl-1h-1,2,4-triazol-5-ylmethoxy pyrazolo 1,5-d 1,2,4-triazine, 5-3-tert-butyl-7-5-methyl-1,2-oxazol-3-yl pyrazolo 1,5-d 1,2,4 triazin-2-yl oxy methyl-1-methyl-1h-1,2,4-triazole
3-[3-tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole
C17H20N8O2
QYSYOGCIDRANAR-UHFFFAOYSA-N
6918583
CC1=CC(=NO1)C2=NN=CC3=C(C(=NN32)OCC4=NC=NN4C)C(C)(C)C

Specifications

MRK 016
783331-24-8
d09ihe, 2-1-methyl-1h-1,2,4-triazole-5-yl methoxy-3-tert-butyl-7-5-methyl-3-isoxazolyl pyrazolo 1,5-d 1,2,4 triazine, 3-1,1-dimethylethyl-7-5-methyl-3-isoxazolyl-2-1-methyl-1h-1,2,4-triazol-5-yl methoxy-pyrazolo 1,5-d 1,2,4 triazine, 3-3-tert-butyl-2-2-methyl-1,2,4-triazol-3-yl methoxy pyrazolo 1,5-d 1,2,4 triazin-7-yl-5-methyl-1,2-oxazole, 3-t-butyl-7-5-methylisoxazol-3-yl-2-1-methyl-1h-1,2,4-triazol-5-ylmethoxy-pyrazolo 1,5-d-1,2,4 triazine, 3-tert-butyl-7-5-methyl-isoxazol-3-yl-2-2-methyl-2h-1,2,4 triazol-3-ylmethoxy-pyrazolo 1,5-d 1,2,4 triazine, 3-tert-butyl-7-5-methylisoxazol-3-yl-2-1-methyl-1h-1,2,4-triazol-5-ylmethoxy pyrazolo 1,5-d 1,2,4-triazine, 5-3-tert-butyl-7-5-methyl-1,2-oxazol-3-yl pyrazolo 1,5-d 1,2,4 triazin-2-yl oxy methyl-1-methyl-1h-1,2,4-triazole
CC1=CC(=NO1)C2=NN=CC3=C(C(=NN32)OCC4=NC=NN4C)C(C)(C)C
368.401
368.39
10mg
C17H20N8O2
QYSYOGCIDRANAR-UHFFFAOYSA-N
3-[3-tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole
6918583
>98%
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