missing translation for 'onlineSavingsMsg'
Learn More

Mouse Thrombopoietin (TPO) Carrier-Free, Invitrogen™

Recombinant Protein

£146.00 - £624.00

Specifications

Name Mouse Thrombopoietin (TPO) Carrier-Free
Recombinant Recombinant
Conjugate Unlabeled
Purity Affinity chromatography
Purification Method SDS-PAGE and HPLC
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15568816
View Documents
Affymetrix eBioscience
34-8686-63
10μg £146.00
10µg View alternative products
Save Up to 
»
Estimated Shipment
30-11-2020
Please to purchase this item. Need a web account? Register with us today!
15578816
View Documents
Affymetrix eBioscience
34-8686-82
100μg £624.00
100µg View alternative products
Save Up to 
»
Estimated Shipment
30-11-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa. Description: Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa. Applications Reported: Recombinant human TPO is biologically active and can promote proliferation of human MO7e cells in culture. Applications Tested: The ED50 of this protein, as measured by proliferation of human MO7e cells, is less than or equal to 1.0ng/mL, which corresponds to a specific activity of at least 1.0 x 10e6 Units/mg. Source: E. coli (amino acids Glu22-Thr195; accession # NP_001166976.1). Bioactivity: The ED50 of this protein, as measured by proliferation of human MO7e cells, is less than or equal to 1.0ng/mL, which corresponds to a specific activity of at least 1.0 x 10e6 Units/mg. Endotoxin: Less than 0.1ng/ug cytokine as determined by the LAL assay. Purity: >98% as determined by SDS-PAGE and HPLC. Molecular Weight: 18.7 kDa. Storage and handling: For best recovery, quick spin vial prior to opening. Use in sterile environment. Reconstitute in water too a concentration of less than or equal to 0.5mg/mL. This protein dissolves slowly. Do not vortex. Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
Specifications

Specifications

Mouse Thrombopoietin (TPO) Carrier-Free
Unlabeled
SDS-PAGE and HPLC
Functional Assays
-20°C
Recombinant
Affinity chromatography
E. coli
18.7