eBioscience™ Human CXCL10 (IP-10), Recombinant Protein, Carrier-Free

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 34-8967-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15588836

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Description and Specification

Specification

Formulation Sterile liquid; phosphate-buffered saline, pH 7.2
Accession Number NM_001565
Recombinant Yes
Purification Method SDS-PAGE
Concentration 0.5mg/mL
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Product Type Recombinant Protein, Carrier-Free
Purity >97%
For Use With (Application) Cytokine Bioassays
Quantity 100μg
Molecular Weight 8.8kDa
Structural Form E. coli-expressed amino acids Val22-Pro98, accession number NM_001565
Source E. coli
Cross Reactivity Human
Gene Symbol Interferon Inducible Protein 10
Conjugate Unlabeled
Name CXCL10 (IP-10)
Biological Activity The bioactivity of this protein was determined by transmigration assay of human T lymphocytes, with maximum chemotaxis observed at 100-200ng/mL.
Regulatory Status RUO
Storage Requirements Store at less than or equal to -70°C.

CXCL10, also known as IP-10 (Interferon Inducible Protein-10), is a member of the CXC family of chemokines. It is secreted by monocytes, epithelial cells, and endothelial cells in response to IFN gamma or other pro-inflammatory cytokines and stimuli. CXCL10 signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. In addition to its role as a chemoattractant, CXCL10 is also a potent inhibitor of angiogenesis and exhibits antitumor activity.