eBioscience™ Human BMP-2, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 34-8507-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15558806

Quantity Price
1 £ 433.49 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Storage Requirements Store at less than or equal to -70°C.
Gene Symbol Bone Morphogenetic Protein 2
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Purity >97%
Name BMP-2
Concentration 0.5mg/mL
Structural Form E. coli expressed amino acids Gln283-Arg396 accession number NP_001191
For Use With (Application) Cytokine Bioassays
Molecular Weight 13kDa
Biological Activity The ED50 of this protein, as determined by alkaline phosphatase induction in C3H/10T1/2 cells, is 0.25-1μg/mL. This corresponds to a specific activity of 4x103 - 1x103 Units/mg.
Purification Method SDS-PAGE
Source E. coli
Product Type Recombinant Protein, Carrier-Free
Regulatory Status RUO
Conjugate Unlabeled
Formulation Sterile liquid: 0.1M glycine, pH 3.0
Accession Number NP_001191
Recombinant Yes
Quantity 100μg
Cross Reactivity Human

BMP-2 is one of fifteen bone morphogenetic proteins (BMP) belonging to the TGF-β superfamily. The BMPs were first identified as the active factors in demineralized bone matrix, with transcripts later being discovered in many other types of tissue. They are synthesized as large precursor molecules that must be cleaved into their active form and dimerize in order to exhibit functional activity. These dimers may include two identical or distinct BMP chains. BMP responsiveness appears to be limited to multipotent and immature cells. The BMPs are essential for osteogenesis and organogenesis during embryonic development, and also play a role in fracture and wound healing in adults.