missing translation for 'onlineSavingsMsg'
Learn More

eBioscience™ Mouse TSLP, Recombinant Protein, Carrier-Free

Mouse Recombinant Protein

Brand:  Affymetrix eBioscience 34-8498-85

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15548806

  • £1607.39 / 500µg


EU Stock 2
Add to basket

Specifications

Description

Thymic Stromal Lymphopoietin (TSLP) is a member of the B cell-stimulating factor family. Originally identified from the conditioned medium of a mouse thymic stromal cell line that promoted B-cell development, TSLP is expressed in thymus, spleen, kidney, lung, and bone marrow. TSLP activity overlaps with that of IL-7, playing a key role in the development of B cells, as well as stimulating the growth of thymocytes and T cells. TSLP stimulates monocytes to produce T cell-attracting chemokines such as TARC (CCL17) and MDC (CCL22). TSLP also activates dendritic cell-primed CD4 T cells to produce Th2 cytokines, including IL-4, IL-5, IL-13, and TNF alpha. This hematopoietic cytokine binds to a heterodimeric receptor complex consisting of the IL-7R alpha chain (CD127) and the TSLP-specific chain (TSLPR). Binding induces activation of STAT3 and STAT5 via phosphorylation. Mouse TSLP shares approximately 43% amino acid sequence identity with human TSLP. Recombinant mouse TSLP is a 15.0 kDa protein consisting of 121 amino acid residues.
Description & Specifications

Specifications

NM_021367
Sterile liquid; 20mM NaH2PO4, 0.15M NaCl, pH 7.2. 0.22μm filtered.
TSLP
>99%
Insect Cells
RUO
Less than 0.1ng/μg cytokine as determined by the LAL assay.
The ED50 tested in a Nag8/7 cell proliferation assay was 0.15ng/mL, corresponding to a specific activity of approximately 6 x 106 Units/mg.
Unlabeled
Yes
Cytokine Bioassays
15-22kDa on SDS-PAGE due to glycosylation.
SDS-PAGE
500μg
Store at less than or equal to -70°C.
Insect cell expressed N-terminal His-Tagged amino acids Tyr20-Glu140 of mTSLP accession #NM_021367
Thymic Stromal-Derived Lymphopoietin
Recombinant Protein, Carrier-Free
Mouse