eBioscience™ Mouse TSLP, Recombinant Protein, Carrier-Free

Mouse Recombinant Protein

Brand: eBioscience™

Manufacturer Part Number: 34-8498-82

100UG Mouse TSLP Recombinant Protein Carrier-Free

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Product Code. 15538806

Quantity Price
1 £1079.80 / 100µg
Estimated Shipment date
from Supplier 26-10-2016
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Description and Specification


Accession Number NM_021367
Conjugate Unlabeled
Cross Reactivity Mouse
For Use With (Application) Cytokine Bioassays
Formulation Sterile liquid; 20mM NaH2PO4, 0.15M NaCl, pH 7.2. 0.22μm filtered.
Molecular Weight 15-22kDa on SDS-PAGE due to glycosylation.
Purification Method SDS-PAGE
Purity >99%
Quantity 100μg
Recombinant Yes
Source Insect Cells
Storage Requirements Store at less than or equal to -70°C.
Regulatory Status RUO
Structural Form Insect cell expressed N-terminal His-Tagged amino acids Tyr20-Glu140 of mTSLP accession #NM_021367
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay.
Gene Symbol Thymic Stromal-Derived Lymphopoietin
Biological Activity The ED50 tested in a Nag8/7 cell proliferation assay was 0.15ng/mL, corresponding to a specific activity of approximately 6 x 106 Units/mg.
Product Type Recombinant Protein, Carrier-Free

Thymic Stromal Lymphopoietin (TSLP) is a member of the B cell-stimulating factor family. Originally identified from the conditioned medium of a mouse thymic stromal cell line that promoted B-cell development, TSLP is expressed in thymus, spleen, kidney, lung, and bone marrow. TSLP activity overlaps with that of IL-7, playing a key role in the development of B cells, as well as stimulating the growth of thymocytes and T cells. TSLP stimulates monocytes to produce T cell-attracting chemokines such as TARC (CCL17) and MDC (CCL22). TSLP also activates dendritic cell-primed CD4 T cells to produce Th2 cytokines, including IL-4, IL-5, IL-13, and TNF alpha. This hematopoietic cytokine binds to a heterodimeric receptor complex consisting of the IL-7R alpha chain (CD127) and the TSLP-specific chain (TSLPR). Binding induces activation of STAT3 and STAT5 via phosphorylation. Mouse TSLP shares approximately 43% amino acid sequence identity with human TSLP. Recombinant mouse TSLP is a 15.0 kDa protein consisting of 121 amino acid residues.