missing translation for 'onlineSavingsMsg'
Learn More

Invitrogen™ Human BAFF (BLyS) Recombinant Protein, eBioscience™

Recombinant Protein

Brand:  Invitrogen™ 14-8943-80

Code : NEW

Additional Details : Weight : 0.09500kg

Product Code. 15517556

  • £214.00 / 25µg
Estimated Shipment: 08-04-2024
to see stock.

Please to purchase this item. Need a web account? Register with us today!


Description

Description

BAFF is a membrane bound cytokine expressed by B cell lineage cells. The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells. BAFF is also expressed by T lymphocytes and has been shown to promote T cell activation and survival. Isoforms representing alternatively spliced, and glycosylated variants have been identified. Description: Recombinant human BAFF (B-cell activating factor), also referred to as BlyS, is a type II transmembrane protein of the TNF superfamily. BAFF is found on T cells, macrophages and dendritic cells. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain which can be cleaved between amino acid 133 and 134 to produce a soluble form detectable in serum. Receptors for BAFF include TACI, BAMBI and BAFFR. BAFF/BLyS is a B lymphocyte stimulatory molecule; it induces B cell proliferation and immunoglobulin secretion. In addition BAFF can provide a co-stimulation signal to T lymphocytes. Elevated levels of BAFF has been implicated in the pathogenesis of some autoimmune diseases (particularly) B cell diseases such as systemic lupus erythaematosus. Human and mouse BAFF share 86% amino acid sequence identity. Applications Reported: Recombinant human BAFF is biologically active. Applications Tested: The ED50, as determined by a mouse splenocytes survival assay, is 1.6ug/mL. Source: E. coli expressed amino acids Ala134-Leu285 accession &Num; Q9Y275. Bioactivity: The ED50, as determined by a mouse splenocyte survival assay, is 1.6ug/mL. Endotoxin: Less than 0.40ng/ug as determined by the LAL assay. Purity: >90% as determined by reducing SDS-PAGE. Molecular Weight: 18.5 kDa. Storage and handling: For best recovery, quick-spin vial prior to opening. Use in a sterile environment. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2um post-manufacturing filtered.
Specifications

Specifications

Q9Y275
Control, Functional Assay
10673
Human CD257 (BAFF, BLyS)
25μg
-80°C
E. coli expressed amino acids Ala134 - Leu285 Accession # Q9Y275
Human CD257 (BAFF, BLyS)
The ED50, as determined by a mouse splenocyte survival assay, is 1.6μg/mL.
Human
Hu
Recombinant
Recombinant
0.1mg/mL
PBS with no preservative
18.5kDa
reducing SDS-PAGE
E. coli
RUO
Less than 0.40ng/μg as determined by the LAL assay.
TNFSF13B
Recombinant Protein
Unconjugated
E. coli
Liquid
Affinity chromatography
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers