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eBioscience™ Mouse TNF-alpha High Sensitivity ELISA

For the quantitative detection of mouse TNF-alpha.

Brand:  Affymetrix eBioscience BMS6001TEN

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15561957

  • £1550.96 / Pack of 10


Estimated Shipment date
from Supplier 26-09-2017
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Disclaimers:

For Research Use Only


Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse IL-17
Biotin-Conjugate anti-mouse IL-17 monoclonal antibody
Streptavidin-HRP
Mouse IL-17 Standard lyophilized, 1ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

Mouse IL-17 mRNA is specifically expressed by activated alpha beta TCR + CD2-CD8-T-cells, a small subset with a potentially important role in immune regulation. IL-17 induces the secretion of IL-6, IL-8, PGE2, MCP-1 and G-CSF by adherent cells like fibroblasts, keratinocytes, epithelial and endothelial cells. IL-17 is also able to induce ICAM-1 surface expression of T-cells. IL-17 has been shown to support the growth of hemopoietic progenitors, it has stimulatory effects on granulopoiesis in mice.

IL-17 may affect osteoclastic resorption and thereby mediate bone destruction accompanying some inflammatory diseases. Astrocytes produce NO when stimulated by IL-17, which suggests a possible role for IL-17 in the inflammatory diseases of the CNS. Forced expression of murine IL-17 induces immune responses and multiorgan inflammation.

Interleukin-17 is involved in the regulation of hematopoiesis and its effects are dependent on the physiological/pathological status of the organism. IL-17 expression in airways is upregulated upon allergen exposure like in allergic asthma. Its crucial role in T-cell activation suggests that IL-17 is involved in the development of autoimmune arthritis.

Specifications

Specifications

Biotin
10 x 96 tests
Cell culture supernatant, serum
Mouse
Interleukin-17, IL-17A, CTLA8
ELISA
1.6pg/mL
50μL
IL-17A