eBioscience™ Mouse CD254 (RANK Ligand), Recombinant Protein

Mouse Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8612-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15567546

Quantity Price
1 £ 207.27 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Purification Method reducing SDS-PAGE
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Quantity 25μg
Storage Requirements Store at less than or equal to -70°C.
Name CD254 (RANK Ligand)
Molecular Weight 20kDa
Conjugate Unlabeled
Biological Activity The ED50, as measured by induction of osteoclast formation on mouse RAW264.7 cells, is 4.8ng/mL.
Purity >90%
Product Type Recombinant Protein
Regulatory Status RUO
Formulation Sterile liquid; phosphate buffered saline, pH 7.2, 1.0% BSA. 0.22μm filtered.
Recombinant Yes
Concentration 0.1mg/mL
Gene Symbol RANKL, TRANCE, Receptor Activator for Nuclear Factor kappa B Ligand, Osteoprotegerin ligand, OPGL, ODF, Osteoclast Differentiation Factor
For Use With (Application) Cytokine Bioassays
Cross Reactivity Mouse
Source E. coli
Structural Form E. coli expressed amino acid Lys158 - Asp316 Accession # Q3TWY5

RANK Ligand (Receptor Activator for Nuclear Factor κB Ligand), also known as TNF-related activation-induced cytokine (TRANCE), along with RANK are members of the TNF superfamily. RANK-L can be found as a soluble protein expressed by activated T lymphocytes, which plays a role in dendritic cell maturation. In addition it has also been shown to be cleaved by TACE (TNF-α convertase) releasing an ectodomain variant of the cell bound form. Lastly RANK-L is expressed as a Type II transmembrane protein expressed by osteoblast lineages. The receptor RANK, located on osteoclastic and dendritic cells can recognize all forms of RANK-L. RANK-L plays a critical role in bone development and mineralization. High levels of RANK-L have been associated with degenerative bone diseases.