eBioscience™ Human BMP-2, Recombinant Protein

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8507-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15517546

Quantity Price
1 £ 176.7 / 25µg
Estimated Shipment date
from Supplier 01-06-2017
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Description and Specification

Specification

Regulatory Status RUO
Accession Number NP_001191
Recombinant Yes
Structural Form E. coli expressed amino acids Gln283-Arg396 accession number NP_001191
Molecular Weight 13kDa
Purity >97%
Concentration 0.1mg/mL
Cross Reactivity Human
Quantity 25μg
Name BMP-2
Conjugate Unlabeled
For Use With (Application) Cytokine Bioassays
Source E. coli
Formulation Sterile liquid; 0.1M glycine, 1% BSA
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Gene Symbol Bone Morphogenetic Protein 2
Product Type Recombinant Protein
Storage Requirements Store at less than or equal to -70°C.
Purification Method SDS-PAGE
Biological Activity The ED50 of this protein, as determined by alkaline phosphatase induction in C3H/10T1/2 cells, is 0.25-1μg/mL. This corresponds to a specific activity of 4x103 - 1x103 Units/mg.

BMP-2 is one of fifteen bone morphogenetic proteins (BMP) belonging to the TGF-β superfamily. The BMPs were first identified as the active factors in demineralized bone matrix, with transcripts later being discovered in many other types of tissue. They are synthesized as large precursor molecules that must be cleaved into their active form and dimerize in order to exhibit functional activity. These dimers may include two identical or distinct BMP chains. BMP responsiveness appears to be limited to multipotent and immature cells. The BMPs are essential for osteogenesis and organogenesis during embryonic development, and also play a role in fracture and wound healing in adults.