eBioscience™ Human Glial Cell Derived Neurotrophic Factor (GDNF), Recombinant Protein

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8506-62

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15587536

Quantity Price
1 £ 84.99 / 5µg
Estimated Shipment date
from Supplier 31-05-2017
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Description and Specification

Specification

Biological Activity The ED50 , calculated by dose-dependent induction of rat C6 cell proliferation, is 1ug/mL, corresponding to a specific activity of 1x103 units/mg.
Quantity 5μg
Formulation Sterile liquid; 10mM phosphate buffer, 150mM NaCl, 1.0% BSA. 0.22μm filtered.
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Recombinant Yes
Cross Reactivity Human
Purification Method SDS-PAGE
Regulatory Status RUO
Purity >98%
Product Type Recombinant Protein
Conjugate Unlabeled
Name Glial Cell Derived Neurotrophic Factor (GDNF)
Storage Requirements Store at less than or equal to -70°C.
Structural Form E. coli expressed amino acids Ser78 - Ile211 Accession # CAG46721
Source E. coli
For Use With (Application) Cytokine Bioassays
Molecular Weight 30kDa (homodimer)

Glial Cell derived Neurotrophic Factor (GDNF), a member of the TGFß superfamily, is a neurotrophic factor that promotes the survival of various neuronal populations in both the central and peripheral nervous systems during their development. Neuronal subpopulations affected by GDNF include motor neurons, midbrain dopaminergic neurons and Purkinje cells. GDNF is conserved across mammalian species with human and rat orthologs sharing approximately 93% amino acid sequence identity. E. coli-produced recombinant human GDNF is a disulfide-linked, non-glycosylated homodimer composed of two 135 amino acid polypeptides.