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Invitrogen™ IL-1 alpha Mouse Uncoated ELISA Kit with Plates

Uncoated ELISA Kit with Plates

£145.00

Specifications

For Use With (Application) ELISA
Synonym Interleukin-1 alpha, IL1F1, Hematopoietin-1
Target Mouse
Sensitivity 4 pg/mL
Storage Requirements 2°C to 8°C
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Products 1
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15550857
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Invitrogen™
88-5019-22
2 x 96 Tests
£145.00
Pack of 2
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Estimated Shipment
11-01-2021
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Description

Description

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Specifications

Specifications

ELISA
Mouse
2°C to 8°C
Interleukin-1 alpha, IL1F1, Hematopoietin-1
4 pg/mL
Mouse
SDS

For Research Use Only