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eBioscience™ Human TPO, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand:  Affymetrix eBioscience 34-8685-63

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15558816

  • £133.91 / 10µg


Estimated Shipment date
from Supplier 27-10-2017
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Description

Description

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
Specifications

Specifications

Functional Assays
18.6kDa
SDS-PAGE and HPLC
10μg
Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
E. coli (amino acids Glu22-Gly195; Accession # AAB33390.1)
THPO, MPL ligand
Recombinant Protein, Carrier-Free
Human
Lyophilized from 10mM sodium citrate, pH 3.0
TPO
>98%
E. coli
RUO
Less than 0.1ng/μg cytokine as determined by the LAL assay
The ED50 of this protein, as measured by proliferation of human MO7e cells, is less than or equal to 1.0ng/mL, which corresponds to a specific activity of at least 1.0 x 106 Units/mg.
Unlabeled
Yes