eBioscience™ Human TPO, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand: eBioscience™

Manufacturer Part Number: 34-8685-61

2UG Human Thrombopoietin (TPO) Recombinant Protein Carrier-Free

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Product Code. 15548816

Quantity Price
1 £ 60.53 / 2µg
Estimated Shipment date
from Supplier 29-03-2017
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Description and Specification


Name TPO
Purification Method SDS-PAGE and HPLC
Purity >98%
Quantity 2μg
Recombinant Yes
Source E. coli
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.
Regulatory Status RUO
Structural Form E. coli (amino acids Glu22-Gly195; Accession # AAB33390.1)
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Gene Symbol THPO, MPL ligand
Conjugate Unlabeled
Biological Activity The ED50 of this protein, as measured by proliferation of human MO7e cells, is less than or equal to 1.0ng/mL, which corresponds to a specific activity of at least 1.0 x 106 Units/mg.
Product Type Recombinant Protein, Carrier-Free
Formulation Lyophilized from 10mM sodium citrate, pH 3.0
Molecular Weight 18.6kDa
Cross Reactivity Human
For Use With (Application) Functional Assays

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.