eBioscience™ Human IL-34, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Overview
Brand: eBioscience™

Manufacturer Part Number: 34-8684-61

2UG Human IL-34 Recombinant Protein Carrier-Free

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15528816

Quantity Price
1 £ 92.2 / 2µg
Estimated Shipment date
from Supplier 23-02-2017
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Description and Specification

Specification

Molecular Weight 52.5kDa
Name IL-34
Purification Method SDS-PAGE and HPLC
Purity >95%
Quantity 2μg
Recombinant Yes
Source HEK 293 cells
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier protein (e.g., 0.1% BSA) at less than or equal to -20°C.
Regulatory Status RUO
Structural Form HEK 293 cells (amino acids Asn21-Pro242; Accession # NP_001166243); contains a C-terminal 8X His tag
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Conjugate Unlabeled
Biological Activity The activity of this protein was determined by measuring MCP-1 secretion from normal human peripheral blood cells.
Product Type Recombinant Protein, Carrier-Free
Cross Reactivity Human
For Use With (Application) Functional Assays
Formulation Lyophilized from 20mM citric acid, pH 3.0

IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.