Invitrogen™ MCP-1/CCL2 Mouse Uncoated ELISA Kit with Plates

Uncoated ELISA Kit with Plates

Product Code	Brand	Quantity
15571137	Invitrogen™ 88-7391-76	20 x 96 Tests
15581137	Invitrogen™ 88-7391-86	10 x 96 Tests
15561137	Invitrogen™ 88-7391-22	2 x 96 Tests

Description

MCP-1 (Monocyte chemotactic protein-1, CCL2) has a predicted molecular weight of approximately 11kDa, however, it may run at a higher molecular weight due to glycosylation. MCP-1 is a member of the cytokine family and plays an important role in immunoregulation and inflammatory processes. MCP-1 signals through G protein-coupled receptors, CCR2 and CCR4, to recruit memory T cells, monocytes and dendritic cells. MCP-1 is linked with tumor progression, angiogenesis, and displays selective chemotactic activity towards monocytes and basophils but not neutrophils or eosinophils. MCP-1 is produced by a variety of cell types and is a potent chemoattractant for monocytes, memory T lymphocytes, and natural killer (NK) cells. Further, MCP-1 is indicated in the etiology of several immune disorders, and is upregulated during infection and inflammation. While MCP-1 is a potent basophil activator, the related protein MCP-2 stimulates both eosinophils and basophils. MCP-3 has been shown to have the broadest range of influence. MCP-1 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis.

Specifications

• For Use With (Application): ELISA
• Target: Mouse
• Storage Requirements: 2°C to 8°C
• Assay Range: 15-2,000 pg/mL
• Product Type: ELISA Kit
• Target Species: Mouse
• Label or Dye: HRP
• Sample Volume: Plasma, 100 μL|Serum, 100 μL|Supernatant, 100 μL
• Total Assay Time: 24 hr. 30 min.

• Synonym: Monocyte chemotactic protein 1
• Sensitivity: 15 pg/mL
• Accession Number: P10148
• Conjugate: Biotin
• Sample Type: Supernatant
• For Use With (Equipment): Colorimetric Microplate Reader
• Regulatory Status: RUO
• Test Time: 1 hr. 45 min.

For Research Use Only