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Invitrogen™ BAFF R (TNFRSF13C) Mouse ELISA Kit

Sandwich ELISA Kit

Brand:  Invitrogen™ EMTNFRSF13C

Code : NEW

Additional Details : Weight : 0.33000kg

Product Code. 15425343

  • £419.00 / 1 set


Estimated Shipment
18-03-2021
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Description

Description

The Mouse BAFF R (TNFRSF13C) ELISA quantitates Ms BAFF R in mouse serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Ms BAFF R. Principle of the method The Mouse BAFF R solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen. Rigorous validation Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
Specifications

Specifications

Q9D8D0
ELISA Kit
28pg/mL to 7,000pg/mL
ELISA, Protein Assays, Protein Biology, Cancer Biology, Immunology, Neuroscience, Neurobiology, Protein Detection, Protein Analysis
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Plasma, 50 μL|Serum, 50 μL|Supernatant, 100 μL
2°C to 8°C
1 hr. 20 min.
Mouse
Immunology
<12%
96 Tests
Supernatant
28 pg/mL
Colorimetric Microplate Reader
HRP
28.67-8000 pg/mL
Biotin
72049
RUO
This ELISA kit shows no cross-reactivity with the following mouse cytokines tested: BTC, C5a, CCL6, CD48, CD6, Chemerin, Clusterin, CXCL15, Cystatin C, DAN, DLL4, EDAR, Endocan, Fetuin A, H60, IL-33, IL-7 R alpha, Kremen-1, Limitin, Lipocalin-2, LOX-1, Marapsin, MBL-2, Meteorin, Nope, NOV, Osteoactivin, OX40, Ligand, P-Cadherin, Periostin, PlGF-2, Progranulin, Prostasin, Renin 1, Testican 3, TIM-1, TRAIL, Tryptase epsilon
96 assays
4 hr. 45 min.
Other Proteins
2010006P15Rik, BAFF-R, Baffr, Bcmd, Bcmd-1, Bcmd1, Lvis22
<10%
Mouse
Solid-phase sandwich ELISA
2010006P15Rik,BAFF-R,Baffr,Bcmd,Bcmd-1,Bcmd1,Lvis22
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