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Tocris Bioscience™ (±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

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Description

Description

RORγt inverse agonist (IC50 = 460 nM). Suppresses Th17 cell differentiation and IL17A expression in vitro. Does not suppress transcription of RORα. Minimal activity displayed on ERα, LXRα and thyroid hormone receptors (IC50 values >4.4 μM).
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