MKL1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA556557

Product Code. 15714471

Description

Immunogen sequence: EQEKRAQQPA PAPAPLGTPV KQENSFSSCQ LSQQPLGPAH PFNPSLAAPA TNHIDPCAVA PGPPSVVVKQ EALQPEPEPV PAPQLLLGPQ GPSLIKGVAP PTLITDSTGT HLVLTVTNKN ADSPG Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 66%.

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Specifications

• Antigen: MKL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mrtfa
• Gene Alias: AMKL; basic SAP and coiled-coil domains; basic SAP coiled-coil transcription activator; basic, SAP and coiled-coil domain; basic, SAP, and coiled-coil domain containing protein; Bsac; FLMKL1; KIAA1438; Mal; megakaryoblastic leukemia (translocation) 1; megakaryoblastic leukemia (translocation) 1 homolog; megakaryoblastic leukemia 1 met; megakaryoblastic leukemia 1 protein; Megakaryoblastic leukemia 1 protein homolog; Megakaryocytic acute leukemia protein; Megakaryocytic acute leukemia protein homolog; MELODY; mixed lineage leukemia; MKL (megakaryoblastic leukemia)/myocardin-like 1; MKL/myocardin-like protein 1; MKL1; MKL1-elongated derivative of yield protein; MKL1met; MRTFA; MRTF-A; myocardin related transcription factor A; myocardin-related transcription factor A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57591
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q969V6
• Gene Symbols: Mrtfa
• Immunogen: Recombinant protein corresponding to Human MKL1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only