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MK 886, Tocris Bioscience™

Inhibitor of 5-lipoxygenase-activating protein (FLAP). Restrictions apply. See special conditions on product page.

Brand:  Tocris (Bio-Techne) 131110

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13459113

  • £170.28 / 10mg


Estimated Shipment
29-11-2018
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Description

Description

An inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Also moderately potent PPARα antagonist (IC50 = 0.5-1 μM). Orally active in vivo.
Specifications

Chemical Identifiers

118414-82-7
472.084
3-3-tert-butylthio-1-4-chlorobenzyl-5-isopropyl-1h-indol-2-yl-2,2-dimethylpropanoic acid, chembl29097, 1h-indole-2-propanoic acid, 1-4-chlorophenyl methyl-3-1,1-dimethylethyl thio-alpha,alpha-dimethyl-5-1-methylethyl-cas, 3-3-tert-butylsulfanyl-1-4-chlorophenyl methyl-5-propan-2-ylindol-2-yl-2,2-dimethylpropanoic acid, 3-3-tert-butylsulfanyl-1-4-chlorobenzyl-5-propan-2-yl-1h-indol-2-yl-2,2-dimethylpropanoic acid, 3-3-tert-butylsulfanyl-1-4-chloro-benzyl-5-isopropyl-1h-indol-2-yl-2,2-dimethyl-propionic acid, tocris-1311, curator_000017, d0k2er, 3-1-4-chlorobenzyl-3-t-butyl-thio-5-isopropylindol-2-yl-2,2-dimethylpropanoic acid
CHEBI:75390
CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl
C27H34ClNO2S
QAOAOVKBIIKRNL-UHFFFAOYSA-N
3651377
3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid

Specifications

MK 886
118414-82-7
3-3-tert-butylthio-1-4-chlorobenzyl-5-isopropyl-1h-indol-2-yl-2,2-dimethylpropanoic acid, chembl29097, 1h-indole-2-propanoic acid, 1-4-chlorophenyl methyl-3-1,1-dimethylethyl thio-alpha,alpha-dimethyl-5-1-methylethyl-cas, 3-3-tert-butylsulfanyl-1-4-chlorophenyl methyl-5-propan-2-ylindol-2-yl-2,2-dimethylpropanoic acid, 3-3-tert-butylsulfanyl-1-4-chlorobenzyl-5-propan-2-yl-1h-indol-2-yl-2,2-dimethylpropanoic acid, 3-3-tert-butylsulfanyl-1-4-chloro-benzyl-5-isopropyl-1h-indol-2-yl-2,2-dimethyl-propionic acid, tocris-1311, curator_000017, d0k2er, 3-1-4-chlorobenzyl-3-t-butyl-thio-5-isopropylindol-2-yl-2,2-dimethylpropanoic acid
CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl
472.084
CHEBI:75390
Solid
10mg
C27H34ClNO2S
QAOAOVKBIIKRNL-UHFFFAOYSA-N
3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid
3651377
472.08
>98%
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