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MK 0343, Tocris Bioscience™

Subtype-selective GABAA receptor partial agonist

Brand:  RD Systems (Bio-Techne) 4415/50

Code : Z1

Additional Details : Weight : 0.00050kg

Quantity 50mg

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Product Code. 13464714

  • £805.08 / 50mg


Estimated Shipment
29-10-2018
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Description

Description

Subtype-selective GABAA partial agonist (Ki values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively); occupies the benzodiazepine site of GABAA receptors. Displays greater agonist efficacy at α3 compared to α1. Exhibits anxiolytic and non-sedating properties in rodent models. Brain penetrant.
Specifications

Chemical Identifiers

233275-76-8
397.39
unii-9vse02330i, 1,2,4-triazolo 4,3-b pyridazine, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, mk hplc, 5-7-cyclobutyl-3-2,6-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazo 4,3-b pyridazine
7-cyclobutyl-3-(2,6-difluorophenyl)-6-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-[1,2,4]triazolo[4,3-b]pyridazine
C19H17F2N7O
GOIFCXRIFSYPFG-UHFFFAOYSA-N
22609888
CN1C(=NC=N1)COC2=NN3C(=NN=C3C4=C(C=CC=C4F)F)C=C2C5CCC5

Specifications

MK 0343
233275-76-8
unii-9vse02330i, 1,2,4-triazolo 4,3-b pyridazine, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, mk hplc, 5-7-cyclobutyl-3-2,6-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazo 4,3-b pyridazine
CN1C(=NC=N1)COC2=NN3C(=NN=C3C4=C(C=CC=C4F)F)C=C2C5CCC5
397.39
397.38
50mg
C19H17F2N7O
GOIFCXRIFSYPFG-UHFFFAOYSA-N
7-cyclobutyl-3-(2,6-difluorophenyl)-6-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-[1,2,4]triazolo[4,3-b]pyridazine
22609888
>99%
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