MICA/B Mouse anti-Human, Alexa Fluor 488, Clone: 6D4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-5788-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15500227

Quantity Price
1 £ 91.11 / 25 tests
EU Stock 2
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Isotype IgG2a
Regulatory Status RUO
Antigen MICA/B
Applications Flow Cytometry
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate Alexa Fluor 488
Concentration 5μL (0.25μg)/test
Quantity 25 tests
Gene Alias MICA/MICB, MICA, MICB
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 6D4
Host Species Mouse
Species Reactivity Human
Primary or Secondary Primary
Format Conjugated

The 6D4 monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I chain-related (MIC), MICA and MICB proteins. MICA and MICB are related proteins of 83% amino acid similarity, and show homology with classical human leukocyte antigen (HLA) molecules. The structure of MICA and MICB are similar to classical HLA class I chains, however they do not bind β2 microglobulin or bind peptide typical of HLA class I. MICA and MICB are expressed on the cell surface of endothelial cells, fibroblasts, gastric epithelium and PHA-stimulated T cells, and act as a ligand for NKGD2 expressed on the surface of NK cells, γδ T cells and αβ CD8+ T cells. There is evidence to suggest that human cytomegalovirus (HCMV) subverts NK cell detection by inhibiting the function of MICB. Furthermore, MICA and MICB expression has been detected in several epithelial tumours isolated from breast, lung, ovary, prostate, colon and kidney.