MHC Class II (I-A/I-E) Rat anti-Mouse, Clone: M5/114.15.2, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5321-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15227417

Quantity Price
1 £ 66.65 / 100µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Quantity 100μg
Antigen MHC Class II (I-A/I-E)
Clone M5/114.15.2
Regulatory Status RUO
Isotype IgG2b
Format Purified
Conjugate Unlabeled
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL
Gene Alias MHC II, IA, IE, I-A/E, IA/IE
Host Species Rat

The M5/114.15.2 monoclonal antibody reacts with the mouse major histocompatibility complex class II, both I-A and I-E subregion-encoded glycoproteins (I-A b, I-A d, I-A q, I-E d, I-E k, not I-A f, I-A k, or I-A s). It detects a polymorphic determinant present on B cells, monocytes, macrophages, dendritic cells, and activated T lymphocytes from mice carrying the H-2 b, H-2 d, H-2 q, H-2 p, H-2 r and H-2 u but not from mice carrying the H-2 s or H-2 f haplotypes. The M5/114 mAb is reported to inhibit I-A-restricted T cell responses of the H-2 b, H-2 d, H-2 q, H-2 u but not H-2 f, H-2 k, or H-2 s haplotypes.