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MERTK Monoclonal Antibody (DS5MMER), PE-Cyanine7, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£82.50 - £233.00

Specifications

Antigen MERTK
Clone DS5MMER
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15538566
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Affymetrix eBioscience
25-5751-80
25 μg
£82.50
25µg
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15548566
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Affymetrix eBioscience
25-5751-82
100 μg
£233.00
100µg
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Description

Description

Description: This DS5MMER monoclonal antibody recognizes mouse MerTK, a 170-210 kDa member of the TAM family of tyrosine kinase receptors that also includes Axl and Tyro3. MerTK is expressed on tissue macrophages and is involved in the removal of apoptotic cells. This process relies on two soluble ligands of MerTK, Protein S and Gas6 that bind to phosphatidylserine found on the outer leaflet of the plasma membrane of cells undergoing apoptosis. Upon binding these ligands, MerTK undergoes autophosphorylation at multiple tyrosine residues that activate the PI3K and Akt pathways. This results in the phagocytosis of apoptotic cells and also results in the direct inhibition of TLR-induced production of pro-inflammatory cytokines. In addition, MerTK may function as a putative entry receptor for filoviruses. Deficiency of MerTK causes general autoimmunity, inflammation and accumulation of apoptotic bodies. MerTK is constitutively released from the cell surface by metalloproteinases and thus is present in the serum and culture medium. This process can be enhanced by stimulation with LPS. MerTK can be used to help discriminate macrophages from dendritic cells. MerTK is often expressed on maligt cells and may be implicated in immune evasion. The DS5MMER antibody will work on paraformaldehyde-fixed cells. Applications Reported: This DS5MMER antibody has been reported for use in flow cytometric analysis.

MERTK Monoclonal antibody specifically detects MERTK in Mouse samples. It is validated for Flow Cytometry.
Specifications

Specifications

MERTK
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Mertk
IgG2a κ
Affinity chromatography
Antibody
DS5MMER
Flow Cytometry
PE-Cyanine7
Rat
Mouse
Q60805
17289
FC-tagged full protein expressed in insect cells
Primary
4° C, store in dark, DO NOT FREEZE!
Mertk
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