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MD-2, clone: 9B4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9928-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258247

  • £69.09 / 25µg


Estimated Shipment
23-02-2018
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Disclaimers:

For Research Use Only.


Description

Description

Description: The 9B4 antibody reacts with human MD-2, an approximately 30kDa molecule, which physically associates with the extracellular domain of TLR4. MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4 since in MD-2(-/-) embryonic fibroblasts, TLR4 was not able to reach the plasma membrane and predominantly resided in the Golgi apparatus, whereas TLR4 was distributed at the leading edge surface of cells in wild-type embryonic fibroblasts. MD-2(-/-) mice do not respond to LPS, do survive endotoxic shock but are susceptible to Salmonella typhimurium infection.Applications Reported: The 9B4 antibody has been reported for use in immunoprecipitation.Applications Tested: This 9B4 antibody has been tested by immunoprecipitation of recombinant MD-2 from cell supernatant. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

MD-2
9B4
Unconjugated
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Immunoprecipitation
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
MD2; Toll-like Receptor
IgG1
RUO
Primary
Human
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