MD-2 Mouse anti-Human, Clone: 9B4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9928-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258247

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Format Purified
Host Species Mouse
Regulatory Status RUO
Quantity 25μg
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C.
Antigen MD-2
Primary or Secondary Primary
Conjugate Unlabeled
Gene Alias MD2; Toll-like Receptor
Isotype IgG1
Clone 9B4
Applications Immunoprecipitation

The 9B4 antibody reacts with human MD-2, an approximately 30kDa molecule, which physically associates with the extracellular domain of TLR4. MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4 since in MD-2(-/-) embryonic fibroblasts, TLR4 was not able to reach the plasma membrane and predominantly resided in the Golgi apparatus, whereas TLR4 was distributed at the leading edge surface of cells in wild-type embryonic fibroblasts. MD-2(-/-) mice do not respond to LPS, do survive endotoxic shock but are susceptible to Salmonella typhimurium infection.