MASH1 Mouse anti-Mouse, Rat, Clone: 24B72D11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5794-82

100UG Anti-Mouse/Rat MASH1 Purified

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15557456

Quantity Price
1 £ 204.0 / 100µg
Estimated Shipment date
from Supplier 07-12-2016
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Description and Specification

Specification

Antigen MASH1
Applications Immunocytochemistry
Applications Immunohistochemistry (Frozen)
Applications Western Blotting
Clone 24B72D11
Concentration 0.5mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Mammalian achaete-scute homolog 1
Host Species Mouse
Isotype IgG1
Quantity 100μg
Regulatory Status RUO
Species Reactivity Mouse, Rat
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The monoclonal antibody 24B72D11 recognizes mouse and rat Mammalian achaete-scute homolog 1 (MASH1), a 34kDa basic helix-loop-helix (bHLH) transcription factor. MASH1, like family members Olig2 and Ngn2, is expressed in progenitor cells throughout the nervous system and retina and is a key regulator of cell fate specification. Expression of MASH1 is regulated by the Delta/Notch1 pathway through direct binding of Hes1 to MASH1 as well as competitive binding to MASH1 hetero-dimerizing proteins. At a transcriptional level, MASH1 expression is controlled by notch-mediated regulation of sox2, which binds to the MASH1 promoter region up-regulating expression. MASH1 has been implicated in the formation of multiple neural cell types including dopaminergic, serotonergic, glutaminergic and GABAergic neurons. Overexpression of MASH1 has been shown in small cell lung carcinoma and medullary thyroid cancer.