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MASH1 Mouse anti-Mouse, Rat, Clone: 24B72D11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5794-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15557456

  • £136.24 / 100µg


Estimated Shipment date
from Supplier 22-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody 24B72D11 recognizes mouse and rat Mammalian achaete-scute homolog 1 (MASH1), a 34kDa basic helix-loop-helix (bHLH) transcription factor. MASH1, like family members Olig2 and Ngn2, is expressed in progenitor cells throughout the nervous system and retina and is a key regulator of cell fate specification. Expression of MASH1 is regulated by the Delta/Notch1 pathway through direct binding of Hes1 to MASH1 as well as competitive binding to MASH1 hetero-dimerizing proteins. At a transcriptional level, MASH1 expression is controlled by notch-mediated regulation of sox2, which binds to the MASH1 promoter region up-regulating expression. MASH1 has been implicated in the formation of multiple neural cell types including dopaminergic, serotonergic, glutaminergic and GABAergic neurons. Overexpression of MASH1 has been shown in small cell lung carcinoma and medullary thyroid cancer.
Specifications

Specifications

MASH1
24B72D11
Unlabeled
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Mammalian achaete-scute homolog 1
IgG1
RUO
Primary
Rat