Lyve-1 Rat anti-Mouse, Biotin, Clone: ALY7, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-0443-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15259559

Quantity Price
1 £ 164.47 / 100µg
EU Stock 4
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Quantity 100μg
Gene Alias Lymphatic Vessel Endothelial Hyaluronan Receptor 1
Concentration 0.5mg/mL
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze.
Format Conjugated
Host Species Rat
Species Reactivity Mouse
Antigen Lyve-1
Clone ALY7
Conjugate Biotin
Monoclonal or Polyclonal Monoclonal
Isotype IgG1

The monoclonal antibody ALY7 recognizes mouse LYVE-1, a transmembrane glycoprotein with similarity to CD44. The extracellular domain contains a conserved hyaluronan binding domain also found in CD44. Expression is found on lymphatic and liver endothelial cells and some populations of macrophages. The lymphatic system is responsible for transporting proteins and cells (especially dendritic cells) to tissues throughout the body, thereby acting as immune surveyors. LYVE-1 is one characteristic protein, along with podoplanin, PROX-1, Tie-2 and VEGFR-3, that is expressed on lymphatic endothelial cells (LECS). The ligand for LYVE-1 is hyaluronan, a large mucopolysaccharide. Although LYVE-1 can bind hyaluronan in vitro, the site for ligand binding in vivo is masked by sialyated O-linked glycan chains. It is postulated that binding to ligand requires modification/unmasking to expose the binding site. The development and remodeling of the endothelium after injury is an area of extensive study. When transplanted, hematopoietic stem cells (HSCs) can give rise to LECs that integrate into the endothelium in normal and metastatic tissue.