Ly-6G (Gr-1) Rat anti-Mouse, Clone: 1A8-Ly6g, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9668-85

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15517836

Quantity Price
1 £ 182.82 / 500µg
EU Stock 2
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Description and Specification

Specification

Quantity 500μg
Species Reactivity Mouse
Regulatory Status RUO
Conjugate Unlabeled
Primary or Secondary Primary
Isotype IgG2a
Host Species Rat
Clone 1A8-Ly6g
Applications Flow Cytometry
Applications Functional Assay
Storage Requirements Store at 2-8°C.
Concentration 1mg/mL
Format Purified
Antigen Ly-6G (Gr-1)
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide

The monoclonal antibody 1A8-Ly6g reacts with mouse Ly-6G, which is also known as Gr-1. Ly-6G is a 25kDa GPI protein expressed exclusively by neutrophils. Studies suggest an important role in neutrophil infiltration, recruitment and migration. Ly-6G associates with B2 integrins CD11a and CD11b and can attenuate B2 integrin expression and function. The ligand for Ly-6G is currently unknown.

Unlike the RB6-8C5 antibody, 1A8-Ly6g is reported to only bind to Ly-6G found on neutrophils. Moreover, 1A8-Ly6g has been used to deplete neutrophils and reported to have antagonist activity.