Ly-6G (Gr-1) Rat anti-Mouse, Clone: 1A8-Ly6g, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9668-85

500UG Anti-Mouse Ly-6G (Gr-1) Functional Grade Purified

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15517836

Quantity Price
1 £ 278.6 / 500µg
Estimated Shipment date
from Supplier 24-02-2017
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Description and Specification

Specification

Antigen Ly-6G (Gr-1)
Format Purified
Formulation aqueous buffer, no sodium azide
Host Species Rat
Applications Flow Cytometry
Applications Functional Assay
Isotype IgG2a
Quantity 500μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone 1A8-Ly6g
Concentration 1mg/mL
Conjugate Unlabeled

The monoclonal antibody 1A8-Ly6g reacts with mouse Ly-6G, which is also known as Gr-1. Ly-6G is a 25kDa GPI protein expressed exclusively by neutrophils. Studies suggest an important role in neutrophil infiltration, recruitment and migration. Ly-6G associates with B2 integrins CD11a and CD11b and can attenuate B2 integrin expression and function. The ligand for Ly-6G is currently unknown.

Unlike the RB6-8C5 antibody, 1A8-Ly6g is reported to only bind to Ly-6G found on neutrophils. Moreover, 1A8-Ly6g has been used to deplete neutrophils and reported to have antagonist activity.