Ly-49H Mouse anti-Mouse, Clone: 3D10, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5886-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15257557

Quantity Price
1 £ 78.88 / 100µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Applications Functional Assay
Applications Immunoprecipitation
Concentration 0.5mg/mL
Host Species Mouse
Conjugate Unlabeled
Storage Requirements Store at 2-8°C.
Isotype igG1
Species Reactivity Mouse
Quantity 100μg
Primary or Secondary Primary
Format Purified
Monoclonal or Polyclonal Monoclonal
Clone 3D10
Regulatory Status RUO
Antigen Ly-49H

The monoclonal antibody 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3+) cells. Natural killer cells can express several Ly-49 proteins. It has been shown that there is preferential staining of Ly-49H with Ly-49D (cat 12-5783). Expression has been confirmed on C57BL/6 and NWNA but not Balb/c or DBA/2 mice. Other mice strains have not been tested. No crossreactivity to Ly-49A, C, D or G2 has been observed. Addition of monoclonal antibody 3D10 to cell cultures induces lysis of target cells.