Ly-49H Mouse anti-Mouse, APC, Clone: 3D10, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5886-82

100UG ANTI-MOUSE LY-49H APC

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15340770

Quantity Price
1 £ 163.0 / 100µg
Estimated Shipment date
from Supplier 23-02-2017
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Description and Specification

Specification

Antigen Ly-49H
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Concentration 0.2mg/mL
Conjugate APC
Format Conjugated
Gene Alias Ly49H
Host Species Mouse
Applications Flow Cytometry
Isotype IgG1
Quantity 100μg
Regulatory Status RUO
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Clone 3D10

The monoclonal antibody 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3+) cells. Natural killer cells can express several Ly-49 proteins. It has been shown that there is preferential staining of Ly-49H with Ly-49D (cat 12-5783). Expression has been confirmed on C57BL/6 and NWNA but not Balb/c or DBA/2 mice. Other mice strains have not been tested. No crossreactivity to Ly-49A, C, D or G2 has been observed. Addition of monoclonal antibody 3D10 to cell cultures induces lysis of target cells.