Ly-49H Mouse anti-Mouse, APC, Clone: 3D10, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5886-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15340770

Quantity Price
1 £ 133.91 / 100µg
Estimated Shipment date
from Supplier 03-05-2017
Add to basket


Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL
Conjugate APC
Primary or Secondary Primary
Antigen Ly-49H
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Host Species Mouse
Clone 3D10
Applications Flow Cytometry
Format Conjugated
Isotype IgG1
Gene Alias Ly49H
Monoclonal or Polyclonal Monoclonal
Species Reactivity Mouse
Regulatory Status RUO
Quantity 100μg

The monoclonal antibody 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3+) cells. Natural killer cells can express several Ly-49 proteins. It has been shown that there is preferential staining of Ly-49H with Ly-49D (cat 12-5783). Expression has been confirmed on C57BL/6 and NWNA but not Balb/c or DBA/2 mice. Other mice strains have not been tested. No crossreactivity to Ly-49A, C, D or G2 has been observed. Addition of monoclonal antibody 3D10 to cell cultures induces lysis of target cells.