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Ly-49D, APC, clone: eBio4E5 (4E5), eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5782-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15340750

  • £69.75 / 25µg


Estimated Shipment
01-05-2019
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Description

Description

Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. Ly-49D, an activating member of the Ly-49 family of NK cell receptors. This family of receptors form homodimers that recognize MHC Class I molecules. The activating Ly-49 receptors (Ly-49D and Ly-49H) do not contain immune receptor tyrosine-based inhibitory motifs (ITIM) in their cytoplasmic domains, distinguishing them from the inhibitory Ly-49 family members. Instead, activating Ly-49 molecules have been shown to associate with DAP12 which contains an immunoreceptor tyrosine-based activation motif (ITAM) that is required for positive signaling. Expression of different Ly-49 family members is not linked, therefore, several Ly-49 proteins can be expressed on the same cells. Expression of Ly-49D on subsets of NK cells is strain-dependent and is found in C57BL/6, CB6F1 and SJL mice, while BALB/c, DBA/2, AKR and CBA/J mice are negative for Ly-49D. In 129/J mice, eBio4E5 also recognizes Ly-49O, Ly-49V and Ly-49R.
Specifications

Specifications

Ly-49D
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q60651
Klra4
IgG2a, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
16635
Flow Cytometry
eBio4E5 (4E5)
APC
Klra4
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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