missing translation for 'onlineSavingsMsg'
Learn More

LY 393558, Tocris Bioscience™

Dual 5-HT1B/1D antagonist and 5-HT re-uptake inhibitor

Brand:  Tocris (Bio-Techne) 335010

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

 View more versions of this product

Product Code. 13442864

  • £163.17 / 10mg

Estimated Shipment date
from Supplier 23-12-2019

Please to purchase this item. Need a web account? Register with us today!


Description

Description

Dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine (Cat. No. 0927) in vivo. Also acts as an antagonist at 5-HT2A and 5-HT2B receptors (pKi values are 7.29 and 7.35 respectively).
Specifications

Chemical Identifiers

271780-64-4
546.676
1-2-4-6-fluoro-1h-indol-3-yl-3,6-dihydro-1 2h-pyridinyl ethyl-3,4-dihydro-3-1-methylethyl-6-methylsulfonyl-1h-2,1,3-benzothiadiazine-2,2-dioxide, 1h-2,1,3-benzothiadiazine,1-2-4-6-fluoro-1h-indol-3-yl-3,6-dihydro-1 2h-pyridinyl ethyl-3,4-dihydro-3-1-methylethyl-6-methylsulfonyl-,2,2
1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-6-methylsulfonyl-3-propan-2-yl-4H-2$l^{6},1,3-benzothiadiazine 2,2-dioxide
C26H31FN4O4S2
QUSLYAPLTMMCFE-UHFFFAOYSA-N
10347428
CC(C)N1CC2=C(C=CC(=C2)S(=O)(=O)C)N(S1(=O)=O)CCN3CCC(=CC3)C4=CNC5=C4C=CC(=C5)F

Specifications

10mg
271780-64-4
1-2-4-6-fluoro-1h-indol-3-yl-3,6-dihydro-1 2h-pyridinyl ethyl-3,4-dihydro-3-1-methylethyl-6-methylsulfonyl-1h-2,1,3-benzothiadiazine-2,2-dioxide, 1h-2,1,3-benzothiadiazine,1-2-4-6-fluoro-1h-indol-3-yl-3,6-dihydro-1 2h-pyridinyl ethyl-3,4-dihydro-3-1-methylethyl-6-methylsulfonyl-,2,2
CC(C)N1CC2=C(C=CC(=C2)S(=O)(=O)C)N(S1(=O)=O)CCN3CCC(=CC3)C4=CNC5=C4C=CC(=C5)F
546.676
546.68
LY 393558
C26H31FN4O4S2
QUSLYAPLTMMCFE-UHFFFAOYSA-N
1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-6-methylsulfonyl-3-propan-2-yl-4H-2$l^{6},1,3-benzothiadiazine 2,2-dioxide
10347428
>98%
Videos
Documents