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LY 364947, Tocris Bioscience™

Selective inhibitor of TGF-βRI

Brand:  RD Systems (Bio-Techne) 27181

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 1mg

 View more versions of this product

Product Code. 13441794

  • £103.95 / 1mg

Estimated Shipment
09-07-2019

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Description

Description

Selective inhibitor of TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-β RI, TGF-β RII and MLK-7K respectively). Inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
Specifications

Chemical Identifiers

396129-53-6
272.311
tbetar-i inhibitor, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, alk5 inhibitor i, tgf-beta ri kinase inhibitor, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, 4-5-pyridin-2-yl-1h-pyrazol-4-yl quinoline, transforming growth factor-beta type i receptor kinase inhibitor, 4-3-pyridin-2-yl 1h-pyrazol-4-yl quinoline, 3-pyridin-2-yl-4-4-quinonyl-1h-pyrazole
4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline
C17H12N4
IBCXZJCWDGCXQT-UHFFFAOYSA-N
447966
C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4

Specifications

LY 364947
396129-53-6
tbetar-i inhibitor, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, alk5 inhibitor i, tgf-beta ri kinase inhibitor, 4-3-pyridin-2-yl-1h-pyrazol-4-yl quinoline, 4-5-pyridin-2-yl-1h-pyrazol-4-yl quinoline, transforming growth factor-beta type i receptor kinase inhibitor, 4-3-pyridin-2-yl 1h-pyrazol-4-yl quinoline, 3-pyridin-2-yl-4-4-quinonyl-1h-pyrazole
C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
272.311
272.31
1mg
C17H12N4
IBCXZJCWDGCXQT-UHFFFAOYSA-N
4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline
447966
>99%
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