LMO2 Mouse anti-Human, Clone: 1A9-3B11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9899-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15218227

Quantity Price
1 £ 182.82 / 100µg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Isotype IgG1
Species Reactivity Human
Primary or Secondary Primary
Clone 1A9-3B11
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Antigen LMO2
Concentration 0.5mg/mL
Applications Immunohistochemistry
Storage Requirements Store at 2-8°C.
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100μg
Host Species Mouse

This 1A9-3B11 monoclonal antibody reacts with human LMO2, a member of the LIM-only family of zinc finger proteins. LMO2 possesses two LIM domains for homodimerization and an N-terminal transactivation domain. This 24kDa transcription factor can be found as part of a transcriptional complex composed of TAL1, E47, GATA-1, and LDB1 proteins. LMO2 is expressed in myeloid cells, germinal center B cells, vascular endothelium, and a variety of cancers, including diffuse large B cell lymphomas (DLBCL), T cell acute lymphoblastic lymphomas, and vascular neoplasms. Expression of LMO2 in germinal center B cells has been shown to be regulated by microRNAs, specifically hsa-miR-223. Although the function of LMO2 remains unclear in germinal center B cells, this factor is involved in hematopoiesis and oncogenesis. In addition, expression of this molecule has been demonstrated to be prognostic marker for survival in DLBCL patients.