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LMO2 Mouse anti-Human, Clone: 1A9-3B11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9899-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15208227

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Disclaimers:

For Research Use Only.


Description

Description

This 1A9-3B11 monoclonal antibody reacts with human LMO2, a member of the LIM-only family of zinc finger proteins. LMO2 possesses two LIM domains for homodimerization and an N-terminal transactivation domain. This 24kDa transcription factor can be found as part of a transcriptional complex composed of TAL1, E47, GATA-1, and LDB1 proteins. LMO2 is expressed in myeloid cells, germinal center B cells, vascular endothelium, and a variety of cancers, including diffuse large B cell lymphomas (DLBCL), T cell acute lymphoblastic lymphomas, and vascular neoplasms. Expression of LMO2 in germinal center B cells has been shown to be regulated by microRNAs, specifically hsa-miR-223. Although the function of LMO2 remains unclear in germinal center B cells, this factor is involved in hematopoiesis and oncogenesis. In addition, expression of this molecule has been demonstrated to be prognostic marker for survival in DLBCL patients.
Specifications

Specifications

LMO2
1A9-3B11
Unlabeled
Purified
IgG1
RUO
Primary
Human
Immunohistochemistry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25μg
Store at 2-8°C.
Monoclonal