LDLRAD4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA564206

Product Code. 15761972

Description

Immunogen sequence: HYKVSTRSFI NRPNQSRRRE DGLPQEGCLW PSDSAAPRLG ASEIMHAPRS RDRFTAPSFI QRDRFSRFQ Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

Specifications

• Antigen: LDLRAD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LDLRAD4
• Gene Alias: 8230401C20Rik; A430083H02; A430108L08Rik; C18orf1; clone 22; D18Ertd653e; D330030L18Rik; Ldlrad4; low density lipoprotein receptor class A domain containing 4; low-density lipoprotein receptor class A domain-containing protein 4; uncharacterized protein C18orf1 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 753
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry
• Concentration: 0.6 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O15165
• Gene Symbols: LDLRAD4
• Immunogen: Recombinant protein corresponding to Human LDLRAD4
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only