LAT Mouse anti-Human, Clone: LAT.10-17 (10-17), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9967-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288287

Quantity Price
1 £ 127.8 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Format Purified
Quantity 100μg
Species Reactivity Human
Applications Immunoprecipitation
Applications Western Blotting
Host Species Mouse
Isotype IgG1
Clone LAT.10-17 (10-17)
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Antigen LAT
Gene Alias Linker for activation of T-cells
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Unlabeled
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Regulatory Status RUO

This LAT.10-17 (10-17) monoclonal antibody reacts with human Linker for Activation of T cells (LAT), which is essential for T cell receptor (TCR)-mediated signal transduction. Characterized as an integral transmembrane protein, this ∽37kDa molecule does not possess a true extracellular domain. Upon TCR/CD3 engagement, LAT localizes to lipid rafts and is tyrosine phosphorylated by ZAP-70, leading to the recruitment and activation of other downstream signaling molecules such as Grb-2, PLCγ, and PI3K. This adapter molecule has been shown to be required for T cell activation, as well as thymocyte and T regulatory cell development. In humans, LAT is expressed on peripheral blood lymphocytes, lymph nodes, and tonsil. Studies in mice have shown that LAT is expressed in thymocytes, T cells, mast cells, natural killer cells, megakaryocytes, platelets, and early B cells. This antibody does not crossreact with the mouse antigen.