LAP Mouse anti-Mouse, PerCP-eFluor 710, Clone: TW7-16B4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-9821-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15371400

Quantity Price
1 £ 189.2 / 100µg
EU Stock 1
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Description and Specification

Specification

Host Species Murine
Quantity 100μg
Isotype IgG1
Concentration 0.2mg/mL
Gene Alias Pro-TGF beta 1, LAP/TGF beta 1
Applications Flow Cytometry
Applications Flow Cytometry (Intracellular Staining)
Primary or Secondary Primary
Conjugate PerCP-eFluor 710
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Mouse
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Antigen LAP
Monoclonal or Polyclonal Monoclonal
Clone TW7-16B4

The TW7-16B4 monoclonal antibody reacts with mouse latency associated peptide (LAP, pro-TGF beta 1, LAP/TGF beta 1). Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types. TGF beta is synthesized as a precursor that contains LAP at the N-terminus and mature TGF beta at the C-terminus. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells. It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells.